1. Inhibitory Antibodies
  2. Rozanolixizumab

Rozanolixizumab  (Synonyms: 洛利昔珠单抗; UCB7665)

目录号: HY-P9979 纯度: 99.34%
COA

Rozanolixizumab (UCB7665) 是一种人源化的高亲和力抗人新生儿 Fc 受体 (FcRn) 单克隆抗体 (IgG4P),用于降低自身免疫和同种免疫疾病中致病性 IgG 的研究。

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CAS No. : 1584645-37-3

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1 mg ¥2800
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5 mg ¥7200
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases[1].

同型

Human IgG4 kappa

推荐同型对照抗体
种属

Chimeric; Humanized

体外研究
(In Vitro)

Rozanolixizumab binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd 23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab is observed to inhibit the recycling (IC50 0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. Recycling of IgG was also inhibits in cynomolgus monkey FcRn-transfected MDCK cells (IC50 0.98nM)[1].
Rozanolixizumab causes an increase in intracellular IgG AF647[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Intravenous (IV) rozanolixizumab dosing in cynomolgus monkeys demonstrated non-linear pharmacokinetics indicative of target-mediated drug disposition; single IV rozanolixizumab doses (30 mg/kg) in cynomolgus monkeys reduced plasma IgG concentration by 69% by Day 7 post-administration. Daily IV administration of rozanolixizumab (initial 30 mg/kg loading dose; 5 mg/kg daily thereafter) reduced plasma IgG concentrations in all cynomolgus monkeys, with low concentrations maintained throughout the treatment period (42 days)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

洛利昔珠单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Loaded Rozanolixizumab on AHC2 biosensor, can bind FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi, HY-P72368) with an affinity constant of 1.430E-10 M as determined in BLI assay.
纯度 & 产品资料

纯度: 99.34%

参考文献

Rozanolixizumab 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Rozanolixizumab
目录号:
HY-P9979
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